Dowd, Terry
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Appointments:
Associate Professor, Chemistry Department, Brooklyn College of the City University of New York
Faculty, Chemistry and Biochemistry PhD Programs, The Graduate Center, The City University of New York
Degrees:
D. Physical Chemistry
Research Focus:
Osteocalcin (5850 MW), is one of the most abundant noncollagenous proteins in bone. Several studies have provided a role for osteocalcin in bone remodeling, enhancing mineral deposition, regulating crystal morphology. Some studies have shown undercarboxylated osteocalcin can activate important membrane receptors, some of which are involved in glucose homeostasis, brain development and function as well as some forms of cancer. My lab investigates protein structure using NMR and x-ray crystallography and investigates the interaction of proteins with membrane receptors. Structural studies of osteocalcin and its interaction with important membrane receptors may shed light on the etiology of some forms of cancer.
Selected Publications
- C.R. Diegel, S. Hann, U.M. Ayturk, J.C.W. Hu, K.E. Lim, C.J. Droscha, Z.B. Madaj, G.E. Foxa, I. Izaguirre, V.V.A. Transgenics Core, N. Paracha, B. Pidhaynyy, T.L. Dowd, A.G. Robling, M.L. Warman, B.O. Williams, An osteocalcin-deficient mouse strain without endocrine abnormalities, PLoS Genet. 16(5) (2020) e1008361.
- Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, Droscha CJ, Madaj ZB, Foxa GE, Izaguirre I, Transgenics Core VVA, Paracha N, Pidhaynyy B, Dowd TL, Robling AG, Warman ML, Williams BO. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020 May;16(5):e1008361. doi: 10.1371/journal.pgen.1008361. eCollection 2020 May. PubMed PMID: 32463812; PubMed Central PMCID: PMC7255615.
- Berezovska O, Yildirim G, Budell WC, Yagerman S, Pidhaynyy B, Bastien C, van der Meulen MCH, Dowd TL. Osteocalcin affects bone mineral and mechanical properties in female mice. Bone. 2019 Nov;128:115031. doi: 10.1016/j.bone.2019.08.004. Epub 2019 Aug 8. PubMed PMID: 31401301; NIHMSID:NIHMS1538856.
- Batir Y, Bargiello TA, Dowd TL. NMR and structural data for Connexin 32 and Connexin 26 N-terminal peptides. Data Brief. 2016 Dec;9:470-476. doi: 10.1016/j.dib.2016.08.044. eCollection 2016 Dec. PubMed PMID: 27722188; PubMed Central PMCID: PMC5048080.
- Batir Y, Bargiello TA, Dowd TL. Structural studies of N-terminal mutants of Connexin 26 and Connexin 32 using (1)H NMR spectroscopy. Arch Biochem Biophys. 2016 Oct 15;608:8-19. doi: 10.1016/j.abb.2016.06.019. Epub 2016 Jul 1. PubMed PMID: 27378082; PubMed Central PMCID: PMC5051353.
- Malashkevich VN, Almo SC, Dowd TL. X-ray crystal structure of bovine 3 Glu-osteocalcin. Biochemistry. 2013 Nov 26;52(47):8387-92. doi: 10.1021/bi4010254. Epub 2013 Nov 12. PubMed PMID: 24138653; PubMed Central PMCID: PMC4517604.
Grants over the last 5 years
R01GM098584 Dowd and Bargiello (PIs) 9/1/12 – 2/29/17
Structure-Function Relation of Connexin Disease Mutations.
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