Shaneen Singh

Singh, Shaneen

Academic Appointments:

Associate Professor, Department of Biology, Brooklyn College, The City University of New York
Faculty, Chemistry, Biology and Biochemistry PhD Programs, The Graduate Center, The City University of New York.

Degrees:

Ph.D. (Biotechnology), Thapar Institute of Engineering and technology, India
M.S. (Biotechnology), Punjabi University, India
B.S.( Life Sciences), Punjabi University, India

Research Focus:

The research focus of my lab is the application of computational approaches to gain insight into cellular signal transduction pathways, and the normal and aberrant functioning of proteins and protein domains. A novel feature of our approach is the integration of bioinformatics tools to analyze genomic and proteomic data with detailed computational analysis of the physical interactions. The computational models that we derive provide novel insights into the molecular basis of the formation and regulation of complexes and, thus, allow us to suggest rational and experimentally testable predictions as to their function. Overall, my lab has extensive expertise in the analysis of protein sequences and structures and is heavily involved in expanding our research to relevant cancer biology questions that encompass several new proteins/protein domains. The current cancer-related projects in the lab involving key protein players in oncogenesis include the interaction of nucleolin with different RNA species, computational characterization of the protein-protein interactions of the  NEK family of proteins, protein-protein interactions of p27, and the membrane-protein interactions of the GAB family of proteins.

Selected Publications:

M Scarpati, Y Qi, S Govind, S Singh. (2019). A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. PloS one 14 (2), e0211897 [PMID: 30753230]

VR Aitbakieva, R Ahmad, S Singh, AV Domashevskiy (2019). Inhibition of ricin A-chain (RTA) catalytic activity by a viral genome-linked protein (VPg) Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1867(6):645-653 [PMID: 30822539]

Heavner, M.E., Ramroop, J., Gueguen, G., Ramrattan, G., Dolios, G., Scarpati, M., Kwiat, J., Bhattacharya, S., Wang, R., Singh, S., Govind, S. (2017) Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila. Current Biology 27, 2869-2877. [PMID: 28889977]

Wiech, E. M., Cheng, H.-P. and Singh, S. M. (2015), Molecular modeling and computational analyses suggests that the Sinorhizobium meliloti periplasmic regulator protein ExoR adopts a superhelical fold and is controlled by a unique mechanism of proteolysis. Protein Science. 24, 319-27 [PMID: 25492513]

Martin C.L., and Singh, S. M. (2015) Identification, modeling, and characterization studies of Tetrahymena thermophila myosin FERM domains suggests a conserved core fold but functional differences. Cytoskeleton. 72, 585-596. [PMID: 26492945]

Grants over the last 5 years:

In silico modeling of p27Kip1 with the Brk SH3 domain and variants to develop a p27drug candidate for treatment in cancer. Concarlo Holdings LLC., $11,188, 1 year (2018-2019)
PSC-CUNY Traditional A : Role of the Gab family pleckstrin homology domains in cancer: A computational study 1 yr ( 2018-2019) $2999
PSC-CUNY Traditional A : Uncovering the membrane targeting mechanism of Class I myosin proteins: A computational study $2570, 1 year (2017-2018)
In silico modeling of p27Kip1 with the Brk SH3 domain and variants to develop a p27drug candidate for treatment in cancer. Concarlo Holdings LLC., $15,000, 1 year (2016-2017)