Anjana Saxena

Saxena, Anjana

Academic Appointments:

2015-present   Associate Professor, Dept. of Biology Brooklyn College CUNY
2009-present   Associate Professor, PhD Advisor in Biology (MCD) and Biochemistry PhD programs, Graduate Center of CUNY
2008-2015      Assistant Professor, Biology Department, Brooklyn College (CUNY), NY.

Degrees:

BS       Microbiology-Biochemistry  Mumbai University, India
MS      Biochemistry                          MS University, Baroda, India
PhD     Applied Biology                     Mumbai University, India 

Research Focus:

I have developed projects encompassing different diseases (e.g. cancer, diabetes, liver diseases) using a variety of cellular and mouse models of cancer (e.g. breast, prostate, pancreas, osteosarcoma) including high-fat diet mouse model for diabetes and liver diseases. In these multifold projects, we focus on few major emerging ideas: (i) How RNA-binding proteins sense cellular stress and control gene regulation during DNA damage response in breast, prostate and pancreatic cancers (ii) How bacterial and fungal microbiome affect cellular immunity in pancreatic carcinogenesis and if any surface markers aid in these processes (iii) How resident microbiome of liver is important in developing the innate immunity, how gut-microbiome is directly implicated in inflammaging and liver diseases including cancer, and how dietary intervention can alleviate the disease progression (iv) How dietary methyl nutrients provide epigenetic regulations in obesity and gestational diabetes. The overarching goals in these studies are to identify potential biological targets for cancer therapy or antimicrobial/nutritional intervention to prevent disease progression. 

Selected Publications (up to 5):

*Corresponding author, aPhD, bMA in Saxena’s lab denoted.

  1. Korsmo HW, Edwards K, Dave B, Jack-Roberts C, Yu H, Saxena A, et al.  Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offspring.Nutrients 2020,  Jan 4;12(1). doi: 10.3390/nu12010144. PubMed PMID: 31947955; PubMed Central PMCID: PMC7019888.
  2. Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim JI, Shadaloey SA, Wu D1, Preiss P, Verma N, Guo Y, Saxena A, et al. The Fungal Mycobiome Promotes Pancreatic Oncogenesis via MBL Activation Nature 2019, 574, 264-267. PMID:31578522, https://rdcu.be/bSQ4t  {Research done during Sabbatical Leave @NYU}. https://www.nature.com/articles/s41586-019-1608-2.
  3. Pushalkar S, Hundeyin M, ….Saxena A, Li X, Cohen D, Sartor RB, Saxena D and Miller G. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discovery 2018 Apr;8(4):403-416. DOI:1158/2159-8290.CD-17-1134; PMID: 29567829; PMCID: PMC6225783.
  4. Zhang X, aXiao S, aRameau RD, Devany E, bNadeem Z, bCaglar E, bNg K, Kleiman FE, *Saxena A. Nucleolin phosphorylation regulates PARN deadenylase activity during cellular stress response. RNA Biol. 2018 Feb 1;15(2):251-260.
  5. Min Dai, Frezzo JA, Sharma E, Chen R, Singh N, Yuvienco C, bCaglar E, aXiao S, Saxena A and Montclare JK. Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery. J Nanomed Nanotechnol 2016,7:1, PMC4828936

 

Patent:

Patent US20040248190“Compositions and kits for differential diagnosis of hydatidiform moles and methods of using the same”. Tycko B., Thaker H. and Saxena, A, 2004.

 

Grants over the last 5 years:

Ongoing Research Support:

The CUNY Enhanced Mechanism (ENHC-51-122), July 2020-June 2021
“Fungal dysbiosis activate pattern recognition receptors pathways and cause immune suppression to promote pancreatic ductal carcinoma (PDA)”
PI: Saxena


The CUNY Interdisciplinary Research Grant (CIRG) Program
June 2018-June 2020 (no cost extension)
“The role of choline in reducing perinatal stress and improving birth outcomes of gestational diabetes in the high-risk urban population”
Multi-PI: Xinyin Jiang (Brooklyn College) and Anjana Saxena (Brooklyn College)


Completed Research Support:

Sackler Institute for Nutrition Research Grant (NYAS)             June 2017-Feb. 2019
“Prenatal betaine supplementation as a treatment for macrosomia in a mouse model of gestational diabetes mellitus”
Multi-PI: Dr. Xinyin Jiang (Nutrition Dept.) and Dr. Saxena (co-PI)


National Health Institute-NIH (NCI)
R21 CA175794:      April 2013-March 2015
“Role of nucleolin in regulating mRNA stability during DNA Damage response (DDR)”
Multi-PI: Dr. Frida Kleiman, Hunter College and Dr. Saxena (Brooklyn College).

CUNY Student Technology Fee (STF): to purchase Odyssey Fc DNA and protein imager (2018)