Lipke, Peter N.
Professor of Biology, Brooklyn College CUNY
BS Chemistry, U. Chicago; PhD Biochemistry, U. California Berkeley
The Lipke has lab long been involved in research that is related to candidiasis and other fungal diseases, which are a cause of morbidity and mortality in a large number of cancer victims. His research interests include structure and function of cell adhesion proteins that mediate pathogen-host interactions and biofilm formation. His extensive work with collaborators in biophysics and medicine, highlights functional amyloids at the cell surface activating cell adhesion, and are potential targets for antifungal drugs. Biofilm formation has been shown to be a factor in the hosting of cancer-causing vectors linked to colon cancer and prostate cancer. Our recent work shows that fungal surface amyloids bind the innate Pattern Recognition Receptor SAP, and this binding leads to induction of an anti-inflammatory response, potentially dampening immune responses to tumors as well. In addition, Dr. Saxena’s recent work shows centrality of fungal infections in pancreatic cancers. Thus, fungal dysbiosis has a key role in cancer development and co-morbidity, so every cancer center therefore has the infectious disease unit that operates to manage fungal pathogenesis in cancer patients.
Selected Publications (up to 5), h value = 41
Jackson, D.N., Kennelly, E., and P.N. Lipke. Method of preventing biofilm formation.
Lipke, P. and U. Edupuganthi. Process for increased yeast biomass.
Grants over the last 5 years
NIH R01 GM098616 A Role for Amyloids in Force-Dependent Activation Of Cell Adhesion (PI/PD Lipke) 6/1/2012-3/31/2017 $1,390,000
Biothera, Inc. Proprietary Strain Production (PI/PD Lipke) 5/16/2011 – 11/30/2015 $775,000